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Treatment of obesity and its comorbidities

University of Zurich

1 semester

Project description

The worldwide rise in obesity is to a large degree responsible for the increased incidence of type 2 diabetes mellitus and cardiovascular diseases. Despite these general developments, body weight is kept relatively constant by a match of energy intake and energy expenditure over long periods. Hence, the system generally seems to detect and correct imbalances between these two factors. The current treatment options against obesity are limited. The most effective option is bariatric surgery, like Roux-en-Y gastric bypass (RYGB) surgery. Interestingly, the treatment success of this intervention appears to be associated with a change in the hormonal profile, in particular in the release of gut hormones, including amylin, which are secreted in larger amounts after RYGB. Our research focusses in particular on the physiology of amylin and its anorectic effect. We also established a strong research program with the only available rodent model of RYGB in Switzerland.

The project is available in the Fall and Spring semester.

The project is open for recently graduated undergraduate students and for graduate students.

Number of places available: 1 per semester.

Faculty Department

Vetsuisse Faculty / Veterinary Physiology

The Institute of Veterinary Physiology is committed to scientific education of their students by teaching them the principles of physiology as well as the newest scientific discoveries. The main emphasis in research of Prof. Lutz’ group is to understand the mechanisms that control the ingestion of food and that contribute to the pathophysiology of obesity and related disorders; another focus is diabetes mellitus in cats:

  • Gastrointestinal hormones in the physiological controls of eating;
  • Factors contributing to the development of obesity and related disorders, e.g. diabetes mellitus and cardiovascular risk factors;
  • Central nervous system control mechanisms;
  • Feline diabetes mellitus.
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