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Design, synthesis and evaluation of covalent chemical probes for labeling of enzymes

ABPP makes use of covalent chemical probes, which are crucial in the labeling of enzymes. Our laboratory has a focus on the synthesis and application of these tools for proteases, and to lesser extent for kinases and ion channels. In this project, you will design, synthesize and evaluate chemical probes for one of these protein classes. Experimental techniques may include solution and solid phase synthesis, compound analysis, gel electrophoresis, enzyme kinetics and cell culture.

  • The project is available in the Fall and Spring semester.
  • The project is also open for recently graduated undergraduate students who have not started yet with their graduate study program.
  • Number of places available: 2 per semester.

Prerequisites

  • Experience with chemical synthesis required.
  • Interest in biochemistry

Faculty Department

Faculty of Biomedical SciencesDept. of Cellular and Molecular Medicine.

The department combines expertise in techniques of bio-organic chemistry, biochemistry, electrophysiology, molecular biology, cell imaging, proteomics, bio-informatics and animal model development to acquire new insights into cellular signaling and communication processes. An additional aim is to decipher the molecular basis for human signal-transduction related diseases and to identify novel therapeutic targets. The department consists of 14 research groups, maintaining close contacts with other departments of the KU Leuven and with the University Hospital. The laboratory of chemical biology specializes in the design and synthesis of chemical probes to  covalently label proteins of interests in cells and cell lysates.