This protein is an endoplasmic reticulum-associated protein, but it was also observed on cell membranes on some cancer cells where it could mediate different signalling pathways involved in apoptosis, cell survival, cell proliferation and inflammation.
Students will contribute to research on the role of GRP78 in ovarian carcinogenesis. The methods used are or could be: cell culture, immunofluorescence, western blot, PCR.
The team set up: 1PhD student, 1 Post doc, 2 lab technicians, 1 visiting professor, and the principal investigator.
Gynaecology and Obstetrics department consists of groups of researchers whose main concern is the women patient. Thus, it directs its research projects towards new therapeutic solutions, improvement of tools for diagnosis, prevention, quality of care and psychosocial-oriented care.
Research presentation by Mishal (DePauw University)
Learn more about Mishal's research project: Cell-Cell FusionWatch Mishal's research presentation
Kylie (University of Denver)
Learn more about Kylie's 2 joint publications: "The Dark Side of Cell Fusion". And "Circulating GRP78 antibodies from ovarian cancer patients: a promising tool for cancer cell targeting drug delivery system?"Read more about Kylie's joint publications